Guillain-Barré syndrome, SARS-CoV-2 and molecular mimicry

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The Guillain-Barré syndrome: a true case of molecular mimicry.

Molecular mimicry between microbial antigens and host tissue forms an attractive hypothetical mechanism for the triggering of autoimmune disease by preceding infections. Recent crucial reviews state that molecular mimicry, as the causative mechanism, remains unproven for any human autoimmune disease. However, the peripheral neuropathy Guillain-Barré syndrome (GBS) is largely overseen in this de...

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Molecular mimicry in Campylobacter jejuni lipopolysaccharides and the development of Guillain-Barré syndrome.

1. Preston D, Therasse D, Zeckel ML. Cefaclor and cefuroxime axetil in the treatment of otitis media—an alternative view [letter]. J Infect Dis 1998;178:1547–8 2. Dagan R, Abramson O, Leibovitz E, et al. Bacteriologic response to oral cephalosporins: are established susceptibility breakpoints appropriate in the case of acute otitis media? J Infect Dis 1997;176:1253–9. 3. Dagan R, Leibovitz E, G...

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Guillain-Barré Syndrome Animal Model: The First Proof of Molecular Mimicry in Human Autoimmune Disorder

Molecular mimicry between self and microbial components has been proposed as the pathogenic mechanism of autoimmune diseases, and this hypothesis is proven in Guillain-Barré syndrome. Guillain-Barré syndrome, the most frequent cause of acute neuromuscular paralysis, sometimes occurs after Campylobacter jejuni enteritis. Gangliosides are predominantly cell-surface glycolipids highly expressed in...

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Characteristics of Guillain-Barré syndrome: brief report

Background: Guillain-Barré syndrome is an autoimmune inflammatory disease, which manifests itself as an acute motor weakness of the organs, diagnosed as affecting the motor spinal nerve roots generally and causing muscle and motor weakness, the cause of this disease is the presence of active antibodies against the myelin sheath around the spinal nerve roots. Guillain-Barré syndrome is the most ...

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Guillain-Barré syndrome.

Guillain Barré syndrome is one of the best examples of a post infectious immune disease and offers insights into the mechanism of tissue damage in other more common autoimmune diseases. Controlled epidemiological studies have linked it to infection with Campylobacter jejuni in addition to other viruses including cytomegalovirus and Epstein Barr virus. The syndrome includes several pathological ...

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ژورنال

عنوان ژورنال: Brain

سال: 2021

ISSN: 0006-8950,1460-2156

DOI: 10.1093/brain/awab067